Nature Reviews Endocrinology
The review summarises newer work on the brain circuits behind vasomotor symptoms such as hot flushes and night sweats. Instead of treating these symptoms as general discomfort, it describes how oestrogen withdrawal can affect KNDy neurons and neurokinin signalling involved in temperature regulation.
The practical point is cautious but useful: non-hormonal options are becoming more biologically targeted, especially relevant for people who cannot or do not want menopausal hormone therapy. Treatment choices still need clinician discussion because eligibility, interactions, and local availability vary.